Hypothyroidism and obesity. Cause or effect?

نویسندگان

  • Abhyuday Verma
  • Muthukrishnan Jayaraman
  • Hari K V S Kumar
  • Kirtikumar D Modi
چکیده

OBJECTIVE To establish relationship between obesity and hypothyroidism and to analyze the frequency the frequency of primary hypothyroidism in obese patients and frequency of obesity in primary hypothyroidism patients. METHODS We conducted this retrospective, observational study in the Department of Endocrinology and Obesity Clinic, Medwin Hospital, Hyderabad, India in Mar 2008. In the last 18 months (between September 2006 to February 2008), data on 625 consecutive primary hypothyroidism patients (Group I) and 450 patients from obesity clinic (Group II) were analyzed. Frequency difference between the 2 groups was assessed by Chi-square test. RESULTS In Group I, 278/625 (44%) had body mass index (BMI) >25 kg/m2. Obesity was higher (46% versus 34%) in overt hypothyroidism than in subclinical hypothyroidism (p=0.21). More patients were overweight in overt hypothyroidism group than in subclinical hypothyroidism group (p=0.02). In obesity patients, overt hypothyroidism was present in 33% and subclinical hypothyroidism in 11% patients. CONCLUSION Overall thyroid dysfunction was found more in obese individuals with varying degree of significance. Detailed studies are required to assess the cause and effect relation between obesity and hypothyroidism.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Prevalence and Correlation of Hypothyroidism With Pregnancy Outcomes Among Lebanese Women

Purpose Assessment of hypothyroidism prevalence and clinical significance among pregnant women in Lebanon. Methods We performed a single-center retrospective cohort study at the American University of Beirut Medical Center. Clinical, demographic, and laboratory data were collected and analyzed using trimester-specific ranges for hypothyroidism. Results Of 920 pregnant women, 17% had hypothy...

متن کامل

Novel Leptin Receptor Mutations Identified in Two Girls with Severe Obesity Are Associated with Increased Bone Mineral Density.

BACKGROUND Recessive mutations in the leptin receptor (LEPR) are a rare cause of hyperphagia and severe early-onset obesity. To date, the phenotype has only been described in 25 obese children, some of whom also had altered immune function, hypogonadotropic hypogonadism, reduced growth hormone secretion, hypothalamic hypothyroidism or reduced adult height. We provide a detailed description of t...

متن کامل

Sleep apnea syndrome and hypothyroidism.

Obstructive sleep apnea syndrome (OSAS) is a serious, prevalent condition that has significant mortality and morbidity when untreated. It is strongly associated with obesity and is characterized by several endocrine and metabolic abnormalities that are frequently more marked than those in obese patients without OSAS, suggesting that factors other than obesity per se have a role in this clinical...

متن کامل

Hashimoto Thyroiditis in Childhood – Review of the Epidemiology, Genetic Susceptibility and Clinical Aspects of the Disease

Chronic autoimmune thyroiditis (chronic lymphocytic thyroiditis or Hashimoto’s thyroiditis) is the most common endocrine disorder in childhood and adolescence. Also it is the most common cause of acquired hypothyroidism in children. Thyroid hormones have critical impact on early brain development, somatic growth, bone maturation; they play a role in synthesis of more than 100 proteins that cons...

متن کامل

Canine Hypothyroidism: Fact or Fiction

Authors almost always refer to hypothyroidism as a common (if not the most common) endocrine disease in dogs, I but there is little evidence to support this claim. In fact, canine hypothyroidism may be one of the most over -diagnosed diseases in small animal medicine. Just about any medical disorder can be associated with decreases in circulating concentrations of thyroid hormone, causing hypot...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Saudi medical journal

دوره 29 8  شماره 

صفحات  -

تاریخ انتشار 2008